Treatment of pain using opioid analgesics

Treatment of pain using opioid analgesics

Opioid analgesics may also be appropriate in many situations.

A non opioid alternative to morphine, it is also easier to use than nitrous oxide.

Mode of action Like the other fibrates, bezafibrate is an agonist of PPARα some studies suggest it may have some activity on PPARγ and PPARδ as well.

Mechanism of action Lorcaserin is a selective 5 HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5 HT2C over other related targets.

The U.S. Food and Drug Administration have approved the use of naltrexone for chronic treatment of opioid dependence and for drug detoxification.

Substitution therapy is the least used approach, possibly reflecting the fact that it is only relevant for opioid dependence and that it is still controversial in some regions.

It's called harm reduction, and it involves, among other things, providing clean needles and syringes, offering opioid substitution therapy and other evidence based treatments to reduce drug dependence.

One study of seventeen patients with intractable cancer pain found that thirteen were virtually pain free and only four required opioid analgesics on release from hospital after the intervention.

Sedation and cognitive impairment usually occur with the initial dose or a significant increase in dosage of a strong opioid, but improve after a week or two of consistent dosage.

Welcoming the fact that the World Health Organization is developing a strategy to integrate the availability of opioid pain medication into palliative care for HIV AIDS, cancer and other chronic diseases,

Welcoming the fact that the World Health Organization is developing a strategy to integrate the availability of opioid pain medication into palliative care for HIV AIDS, cancer and other chronic diseases,

In all cases, intervention needs to be tailored to the changing needs of specific target groups, such as young cannabis and amphetamine type stimulants (ATS) users, injecting opioid users and offenders.

Fentanyl (also known as fentanil, brand names Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis, Instanyl, Abstral, Lazanda and others) is a potent, synthetic opioid analgesic with a rapid onset and short duration of action.

At the same meeting, the Council adopted draft resolution I recommended by the Commission, entitled Treatment of pain using opioid analgesics , contained in chapter I, section B of the report.19 See Council resolution 2005 25.

In its resolution 2005 25, entitled Treatment of pain using opioid analgesics , the Economic and Social Council requested the Secretary General to report to the Commission at its forty ninth session on the implementation of the resolution.

Calling attention to the assessment of the International Narcotics Control Board in its report for 2004 according to which low consumption of opioid analgesics for the treatment of moderate to severe pain, especially in developing countries, continued to be a matter of great concern to the Board,

Calling attention to the assessment of the International Narcotics Control Board in its report for 2004 according to which low consumption of opioid analgesics for the treatment of moderate to severe pain, especially in developing countries, continued to be a matter of great concern to the Board,

Recognizes the importance of improving the treatment of pain using opioid analgesics, especially in developing countries, and calls upon Member States to take steps to facilitate the medical use of those narcotic drugs, taking fully into account the need to prevent their diversion for illicit use

In some cases, more accurate reporting may be behind an apparent decrease in coverage, as some countries not having substitution treatment (mostly not relevant because of the low prevalence of opioid dependence in the region) went from reported high levels of coverage in 2000 2002 to 0 in 2002 2004.