The Krebs cycle, or the citric acid cycle.

This long talked about Krebs cycle.

This is where our Krebs cycle occurred.

Krebs cycle or the citric acid cycle gets credit for this step.

Then we're ready to enter the Krebs cycle.

And then they enter into what's called the Krebs cycle.

But it's really a preparation step for the Krebs cycle.

Everything in the Krebs cycle is an enzyme catalyzed reaction.

So they'll say eight NADHs get produced from the Krebs cycle.

Glycolysis, the preparatory stage and the Krebs or citric acid cycle.

But it's normally viewed to be after glycolysis and the Krebs cycle.

But then you move over to the Krebs cycle, which is aerobic.

So we have this kind of preparation step for the Krebs Cycle.

Now, in the citric acid cycle, or in the Krebs cycle, well first we have our pyruvate oxidation.

And then the citric acid is oxidized through the Krebs cycle right there.

Now, sometimes in a lot of books these two NADHs, or per turn of the Krebs cycle, or per pyruvate this one NADH, they'll give credit to the Krebs cycle for that.

Now you have these pyruvates, they're not quite just ready for the Krebs cycle, but I guess well that's a good intro into how do you make them ready for the Krebs cycle?

But the reality is, six from the Krebs cycle two from the preparatory stage.

Then those byproducts are split even more in the Krebs cycle, directly producing two ATPs.

And then you go to the Krebs cycle, there's a little bit of setup involved here.

And then when we look at this side, the formal Krebs cycle, what do we get?

But the interesting thing is that the Krebs cycle is the entry point for these other catabolic mechanisms.

You'll have some NAD plus, which you can then go and use back in the Krebs Cycle and in glycolysis.

The Krebs cycle is really formally this part where you start with acetyl CoA, you merge it with oxaloacetic acid.

So, so far, if you include the preparatory step, we've had four NADHs formed, three directly from the Krebs cycle.

And then, and this is kind of the interesting point, there's another process that you can say happens after the Krebs cycle.

Now once you have this 2 carbon chain, acetyl Co A right here. you are ready to jump into the Krebs cycle.

And then most especially introductory textbooks will give the Krebs cycle credit for this pyruvate oxidation, but that's really a preparatory stage.

After being done with glycolysis and the Krebs

You get two NADHs and you get two pyruvates, which are going to be re engineered into acetyl CoAs that are going to be the raw materials for the Krebs cycle.

Krebs is a city in Pittsburg County, Oklahoma, United States.

But if we have oxygen and for the most part we're going to assume that we can proceed forward with oxygen if there is oxygen, then we could proceed forward to the Krebs cycle.

But the big picture here is acetyl CoA is the general catabolic intermediary that can then enter the Krebs cycle and generate ATP regardless of whether our fuel is carbohydrates, sugars, proteins or fats.

After a brief illness, Krebs died on 22 November 1981 in Oxford.

Edwin Gerhard Krebs (June 6, 1918 December 21, 2009) was an American biochemist.

If we have oxygen we can move to the Krebs cycle, get our two ATPs, and then go on to the electron transport chain and produce 34 ATPs, which is really the bulk of what happens in respiration.

and I know this gets complicated here but I think over the course of the next few videos we'll get an intuition for it in these two parts of the reaction, glycolysis and the Krebs cycle, we're constantly taking NAD

Cycle

Cycle

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