The iris of the eye is brown and has a single incomplete row of eyelashes on the upper lid and two rows on the lower lid.

In lid lag (von Graefe's sign), when the patient tracks an object downward with their eyes, the eyelid fails to follow the downward moving iris, and the same type of upper globe exposure which is seen with lid retraction occurs, temporarily.

Application requires pulling down the eyelid and applying a small amount (0.25 in) inside.

This is thought to be a form of localized angioedema, or rapid accumulation of fluid in the tissues.

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Such a routine needs to be convenient enough to be continued for life to avoid relapses as blepharitis is often a chronic condition.

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Chronic progressive external ophthalmoplegia is a systemic condition that occurs suddenly and which usually affects only the lid position and the external eye movement, without involving the movement of the pupil.

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