His irritability, though it might have been comprehensible to an urban brain worker, was an amazing thing to these quiet Sussex villagers.

The sensitive reactions display a variety of symptoms such as insomnia, difficulty in concentrating, anxiety, irritability, headaches, dizziness and other similar responses.

The symptoms that Hippocrates associated with melancholic disorder aversion to food, despondency, sleeplessness, irritability, restlessness are remarkably similar to those contained in modern definitions of depressive disorder.

Roughly 10 of people who smoke cannabis go on to develop dependence, which produces withdrawal symptoms when use is stopped, such as craving, irritability, sleep disturbances, abdominal pain, and nervousness.